We conduct extensive shelf life testing on our formulas, including a series of freeze/thaw cycles as well as various additional temperatures. Generally, freezing should not affect the efficacy of the product and we suggest you allow it to sit in room temperature for a few hours prior to use. We do, however, advise that our products are not exposed to high temperatures as many of our formulations contain antioxidants that are sensitive to extreme heat. For this reason, we recommend that you store AlumierMD products in a cool, dark place.